Colossus Hammer, Belt of Giant Strength, and Argentum Armor to (hopefully) make our commander the biggest creature on the board just by themselves
In FF7 , Jenova is described as a calamity that fell from the sky long ago. Shes not a mutant herself but is instead an alien with a mutable genetic structure, absorbing the traits of beings she encounters while also inserting her own DNA into them, transforming them into mutants that eventually can turn into monsters
The Wind Crystal gives all your creatures flying and lifelink, which can lead to massive lifegain and mill
Hark, hear the Chocobo call forth
Arcades went on to be a very popular toughness-matters Commander, and it took seven years and a return to Tarkir to gives us Felothar, a similarly strong Abzan version of this iconic Commander
When non-Evasive characters like Aladdin, Heroic Outlaw and Mad Hatter, Gracious Host hit the board, you have tools like Shield of Virtue and Fan the Flames that can keep them safe from challenges