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As a widespread model animal in research areas such as development, molecular genetics, toxicology and biomedicine 26,27 , zebrafish ( Danio rerio ) has been used in mechanistic studies of fish nutrition 28,29

Early research connected it with sleep physiology, especially delta sleep, which refers to slow-wave brain activity often associated with deep sleep

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One such protein is CREB, a transcription factor that responds to signals from anti-inflammatory factors such as IL-4, IL-10, IL-13, TGF-, and NGF

The molecule was derived from sermorelin (native GHRH 1-29) by four protease-resistance substitutions (D-Ala at position 2 blocks DPP-IV cleavage

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