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[1] [4] Clinical trials have documented modest increases in resting heart rate (typically 2-5 beats per minute) with semaglutide

The GLP-1 receptor (GLP-1R) is widely expressed in other tissues

This matters because lying flat with active nausea is miserable

However, lying flat can actually encourage gas to travel back up the esophagus

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In a rat model of cerebral ischemia-induced neurological impairment, the co-administration of tissue plasminogen activator (tPA) with nanoliposomal Fasudil-Lip showed better neuroprotection, and prolonged therapeutic time window (TTW) and improved drug targeting (Fukuta et al., 2017)