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While injectable GLP-1 medications generally have no direct pharmacokinetic interaction with levothyroxine, there are important considerations regarding oral semaglutide and indirect effects that warrant attention
Because Pendulum can increase GLP-1 production, and GLP-1 affects insulin secretion, combining the supplement with insulin or sulfonylureas could theoretically increase hypoglycemia risk
10.1056/NEJM199012133232404 141 WuA
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IUBMB Life 71 (4), 456-478
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